![]() ![]() ![]() ![]() Over the past decade, the concerted efforts of many groups, including ours, have revealed that human NKX3.1 functions as a prostate-specific tumor suppressor. Our longstanding interest in of homeobox gene function in mouse development intersected with human prostate cancer with the discovery of the mouse Nkx3.1 gene. We employ techniques that reach from the whole animal down to post-translational modification of individual proteins to bring the full spectrum of modern genetic, cellular, molecular biological, and biochemical approaches to bear on each problem. The major focus of our work is to explore issues at the interface between development and human disease, with a view towards identifying novel points of therapeutic intervention. As our understanding of the fundamental processes underlying animal growth and differentiation from zygote to adult has increased, it has become clear that changes in developmental pathways often underlie disease. PhD, Johns Hopkins University, 1987 Professional InterestsÄ®xploring the interface between development and cancerÄuring the past two decades, the molecular basis of animal development has been investigated with an ever-increasing arsenal of genetic and biochemical tools.
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